CONCYTEC

 

CONCYTEC

Coronavirus COVID-19
Publicaciones seleccionadas
por el CONCYTEC
ABSTRACT
An unprecedented effort is under way to rapidly develop Covid-19 vaccines, with pharmaceutical companies, academic researchers, and government agencies aiming to compress into several months a process that typically requires at least several years. This work is supported by extraordinary public and private investments and by newly created entities such as Operation Warp Speed. Concurrent with clinical testing of vaccine candidates, new mechanisms are being established to expedite manufacturing ahead of a future vaccination campaign. Critical decisions will soon need to be made, including evaluations of data on vaccine safety and efficacy, which could lead to the approval of one or more products and the development of recommendations for deployment.
ABSTRACT
"Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impacts on economic, social, and health care system. Uncertainties regarding coronavirus disease (COVID-19) promote concerns in choosing the best therapeutic strategy. Several drugs with antiviral effects were prescribed to treat COVID-19, but scientific evidence is not conclusive about benefit. Unnecessary antimicrobial use may cause an increase in multidrug-resistant organisms.1,2 It is necessary to consider actions to prevent consequences that COVID-19 may have on antimicrobial use.1,2 Antibiotic Stewardship is a strategy to promote the optimal use of antibiotics. The COVID-19 probably changes the antibiotic consumption profile and it is necessary to measure it. Thus, our goal was to evaluate the impact of the pandemic on antimicrobial usage patterns comparing cohorts of COVID-19 positive and COVID-19 negative patients admitted in specific hospital locations."
ABSTRACT
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; disease prognosis is influenced mainly by multi-organ involvement. Acute respiratory distress syndrome, heart failure, renal failure, liver damage, shock and multi-organ failure are strongly associated with morbidity and mortality. The COVID-19 disease pathology is plausibly linked to the hyperinflammatory response of the body characterized by pathological cytokine levels. The term ‘cytokine storm syndrome’ is perhaps one of the critical hallmarks of COVID-19 disease severity. In this review, we highlight prominent cytokine families and their potential role in COVID-19, the type I and II interferons, tumour necrosis factor and members of the Interleukin family. We address various changes in cellular components of the immune response corroborating with changes in cytokine levels while discussing cytokine sources and biological functions. Finally, we discuss in brief potential therapies attempting to modulate the cytokine storm.
 

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