CONCYTEC

 

CONCYTEC

Coronavirus COVID-19
Publicaciones seleccionadas
por el CONCYTEC
catatula.png
ABSTRACT
Unprecedented public health interventions including travel restrictions and national lockdowns have been implemented to stem the COVID-19 epidemic, but the effectiveness of non-pharmaceutical interventions is still debated. We carried out a phylogenetic analysis of more than 29,000 publicly available whole genome SARS-CoV-2 sequences from 57 locations to estimate the time that the epidemic originated in different places. These estimates were examined in relation to the dates of the most stringent interventions in each location as well as to the number of cumulative COVID-19 deaths and phylodynamic estimates of epidemic size. Here we report that the time elapsed between epidemic origin and maximum intervention is associated with different measures of epidemic severity and explains 11% of the variance in reported deaths one month after the most stringent intervention. Locations where strong non-pharmaceutical interventions were implemented earlier experienced much less severe COVID-19 morbidity and mortality during the period of study.
catatula.png
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is pandemic. Prevention and control strategies require an improved understanding of SARS-CoV-2 dynamics. We did a rapid review of the literature on SARS-CoV-2 viral dynamics with a focus on infective dose. We sought comparisons of SARS-CoV-2 with other respiratory viruses including SARS-CoV-1 and MERS-CoV. We examined laboratory animal, and human studies. The literature on infective dose, transmission, and routes of exposure was limited specially in humans, and varying endpoints were used for measurement of infection. Despite variability in animal studies, there was some evidence that increased dose at exposure correlated with higher viral load clinically, and severer symptoms. Higher viral load measures did not reflect COVID-19 severity. Aerosol transmission seemed to raise the risk of more severe respiratory complications in animals. An accurate quantitative estimate of the infective dose of SARS-CoV-2 in humans is not currently feasible and needs further research. Our review suggests it is small, perhaps about 100 particles. Further work is also required on the relationship between routes of transmission, infective dose, co-infection, and outcomes.
catatula.png
ABSTRACT
Objective: This study aimed to address the key areas of concern for child nutrition, both during and after the COVID-19 pandemic, and proposes strategic responses to reduce child undernutrition in the short and long term. Design: A descriptive literature review was performed. The search of the literature was conducted through using electronic databases including PubMed, Web of science, google scholar, and Cochrane library. Setting: A wide range of published articles focused on child malnutrition were reviewed. Participants: The study was focused on children especially those under five years. Results: This study proposes strategic responses to reduce child undernutrition. These responses include strengthening access to community-based nutrition services that support the early detection and treatment of undernourished children and emergency food distribution, including fortified foods with vitamins and minerals, to vulnerable households, particularly those with children under five years. Moreover, counseling and promotion programs should be reinforced to revitalize community nutrition education in areas such as gestation, exclusive breastfeeding, and complementary feeding, and hygienic practices involving handwashing, proper sanitation, and other basic behavioral changes. Conclusions: The COVID-19 pandemic has affected many countries especially those in the regions of South Asia and sub-Saharan Africa in which there has been an ongoing burden of child undernutrition. However, malnutrition is preventable and can be eliminated through a multisectoral strategic approach. The effective execution of a multisectoral approach toward preventing childhood malnutrition will require not only a financial investment but also the collective efforts from different ministries of the governments, UN-affiliated agencies, and nongovernmental organizations.
 

Contáctenos

Calle Chinchón Nº 867 - San Isidro

Lima - Perú

Central Teléf.: (051- 1) 399  0030

biblioteca@concytec.gob.pe 

 Facebook Twitter RSS  top youtube